7/23/2004: Must We Grow Old? - Redux, Part 2 This second section in a series for "Gift of Fire" deals with trans (partially hydrogenated) fats.
6/16/2004: An expanded version of the "Must We Grow Old - Redux?" article for "Gift of Fire".is available here (in html format). This, and the original print-formatted version of the article (requires Microsoft Word), appearing in the June, 2004, issue of "Gift of Fire", gives an introductory overview of caloric-restriction.
6/12/2004: Metabolic Rates and Aging
This brief discussion reports on a study that shows, to everyone's surprise, that among a given species of mice, the mice with the highest metabolic rates lived the longest. One would normally expect the exact opposite: that the mice that 'lived slowest" would age slowest.
The original paper, Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer, appears in a June, 2004, issue of Nature.
A similar result has been observed with fruitflies, for which no correlation was found between lifespan and metabolic rate.
6/1/2004: One View of the State-of-the-Art in the Retardation and Reversal of Aging
This disquisition reviews a paper published in February, 2004, in the Journal Physiological Genomics and Physiology that compares the gene-chip profiles of semi-starving rats with caloric-restricted rats and with rats fed only glucose. This 61-page paper identifies 261 out of 20,000 liver genes that change when mice are forced to fast for 24 hours and for 48 hours (which is a long time between meals for a mouse). The paper also examines the roles of some of these genes in various metabolic cycles within the liver cells.
5/23/2004: Does Mother Nature Have Some Rejuvenation Tricks Up Her Sleeve?
This "editorial" argues that we may not need a full scientific understanding of aging in order to find ways of circumventing it... basically, the engineering argument made by Aubrey de Grey. It also suggests that, because changes in such parameters as blood lipid profiles, fasting blood sugar levels, fasting insulin levels, etc., change rapidly when someone loses weight and goes on caloric-restriction, it should be feasible and important to run studies to:
(1) measure the rates of change of these "health indices" as a function of time, of weight, and of age; and
(2) measure the rates of change of these "health indices" using metformin with and without caloric-restriction.
Since the costs of basic tests of these serum profiles are minimal, it might be possible to get volunteers to foot the bills for 3 or 4 SMAs.
A principal question might be the willingness of subjects' private physicians to monitor the metformin administration. Also, if they have to prescribe metformin to these non-diabetic volunteers, that could be a problem.
Alternatively, pre-diabetic subjects might be chosen.
5/17/2004: How Reversible Are Caloric-Restriction "Rejuvenations"?
This deals with the surprising fact that the age-reversal gene changes observed with caloric restriction disappear when caloric restriction is eliminated. One of the questions is: what would happen if subjects went back on a semi-ad-lib diet, but maintained their reduced weights? Also, do structural changes such as the 40% diminution of the carotid atrtery intima walls in the Washington University study tend to remain after caloric restriction ends?
4/28/2004: I had posed several questions in Yesterday's Chart Re-examined. One of them was: how much does a 20% weight loss reduce the calories required to maintain that lower weight? Here's the answer.
4/24/2004: Yesterday's Chart Re-examined
4/21/2004: I don't know to what extent this will be of general interest, but here it is.
4/19/2004: Interesting News
4/11/2004: Rejuvenation Update - III
4/9/2004: Rejuvenation Update - II
4/8/2004: Rejuvenation Update - I
4/3/2004: Meanwhile, in an Adjoining Theater...
4/2/2004: More on Rejuvenation
4/1/2004: Subtracting 15 Years From Your Age?
3/31/2004: Adding Decades to Your Life Span?
3/30/2004: Antioxidants - To Supplement Or Not To Supplement?
3/29/2004: Does Caloric Restriction Reverse Aging (As Opposed to Merely Slowing It)?
3/28/2004: The Effects of Nutritional Supplements Upon the Life Spans of Mice
3/24/2004: Mocrosoft and Resveratrol
3/13/2004: Here's a second installment of A Prolongevity Update - 2
3/11/2004: A Prolongevity Update
3/9/2004: Chirp, Chirp!
3/4/2004: More Notes from Your Canary
3/3/2004: News Commentaries
2/29/2004: Your Health and Your Lifespan - 3
2/28/2004: Your Health and Your Lifespan - 2
2/27/2004: Your Health and Your Lifespan
2/18/2004: I had promised to post my bloodwork as soon as I got it so that it could be compared with Tommie's. The question is whether or not our diets, supplements, etc., have delivered noticeable benefits. So here are the results
2/16/2004: Another Chirp or Two from Your Canary
2/4/2004: Another Lilting Aria from Your Canary
12/26/2003: What It's Like to be on a Caloric-Restricted Diet
12/15/2003: Your Canary Chirps Again.
11/17/2003: Your canary reports from the mine shaft.
10/29/2003: Slowing Your Rate of Aging? - Rewritten Today's updates are in carmine.
2/26/2003: "The Singularity" and Transhumanism-2
2/23/2003: "The Singularity" and Transhumanism
2/1/2003: A Prolongevity Article
1/5/2003: Ageing process 'key' pinpointed - BBC
12/26/2002: .Aging and Cancer
12/23/2002: .The Aging of Skin
12/21/2002: .There is a discussion of nutrition and a few degenerative diseases on the Life Extension Foundation website
12/3/2002: Gerontocracies - 2
12/2/2002: Gerontocracies - 1
11/30/2002: Prolongevity Again (Social Aspects)
11/25/2002: A Little More on Aging
11/24/2002: Aging and the Environment
11/19/2002: More News Items
11/8/2002: Here is Part 2 of a Presentation on Prolongevity
10/29/2002: An Ounce of Prevention Is Worth a Pound of Cure
10/23/2002: Dropping the Other Shoe
10/16/2002: Final Comment
10/15/2002: Does Preservation of Older Members Affect Species Survival?
10/14/2002: ."When the Cat's Away...."
10/13/2002: Telomerase and Cancer, Take 3
10/10/2002: Telomerase and Cancer, Take 2
10/9/2002: .Telomerase and Cancer.
10/5/2002: And here's the article.
10/4/2002: Today was occupied with the preparation of an article on aging interventions for "Gift of Fire"
In this regard, I might update my and Tommie's experiences with "mind boosters" and nutritional supplements. I've upped our dosages of alpha-lipoic acid to 100-to-400 mg. a day, and the acetyl-l-carnitine to 500 mg. a day. Last spring, I'd been concerned that such doses might be interfering with our sleeping patterns, but I don't see any evidence of that now. Is it helping? I honestly can't say.
I bought a book entitled, "The Wrinkle Cure" by a Yale School of Medicine dermatologist by the name of Nicholas Perricone, MD. In it, he advocates the use of alpha-lipoic acid, vitamin-C esters (e. g., calcium ascorbate), vitamin E (in the form of mixed tocotrienols), DMAE (dimethylaminoethanol), and alpha-hydroxy and beta-hydroxy acids. Another useful ingredient is coenzyme Q-10. He also recommends strawberries and blueberries.
I'm about to try adding my own ingredients to a cheap skin lotion from Walmart. I'll let you know what happens. (I'm interested in anti-aging technology, and the skin is an effective test-bed.)
I've also mentioned experimenting with a skin cream that's supposed to be Dimericine in disguise, containing a DNA repair enzyme. I tried it for two weeks on the back of my left hand and then quit for a while. If it really repairs DNA, then it should require constant application. I decided to wait for a couple of weeks before continuing to see what would happen. Has it shown any improvement? The effects haven't been sufficiently dramatic that I can say with confidence that it's having any effect. The creases where I bend my left wrist are spread out over about two inches, whereas the creases on my right hand are spread out over about an inch. That makes the two hands difficult to compare.
Tonight, I took a close look at Tommie's facial skin. It's a wonder to behold. Tommie has slight lines at the corners of her mouth, but otherwise, looks very, very young. Tommie has always avoided the sun, and has cared for her skin with moisturizers every night since girlhood.
10/3/2002: The BBC has an interesting article today that a class of medications used to treat hypertension in diabetes may be causing some degree of aging retardation. These medications are angiotensin conversion enzymes (ACE's) used to lower blood pressure by reducing advanced glycation end products. Advanced glycation end products are proteins that have been "curdled", similar to the tanning of leather. Unlike other blood pressure medications, ACE's seem to reduce the stiffening of the arteries, and of other endothelial and epithelial tissues, including the skin.
Patrick Wahl has raised an interesting question: Could living at high altitudes reduce the rate of oxidation of tissues, and perhaps, even slow the metabolism in a manner similar to caloric restriction? If so, we'd expect that people that live at high altitudes would tend to live longer than us low-landers. And there's some evidence to support that idea.
9/30/2002: Here's a first cut at some ideas for (let's hope) maximizing your longevity (based upon my recent readings)
9/28/2002: I'm beginning to get ideas regarding longevity research. I have also found some excellent links (The Owner's Manual for the Human Body), together with information regarding some mechanisms of aging, and what kinds of diets might minimize aging. I continued updating the Prolongevity_Discussion
9/27/2002: On the 15th of this month, I found the Prolongevity_Discussion at the top of the Google search list for "Prolongevity", so I spent the day changing it to something that I thought was more suitable. Today, I encountered it at the top of another engine's search list, and was appalled at the pettiness and peevishness of what I'd written. So today, I rewrote it again. I hope I don't read it again come October 10th and decide that it's still pretty terrible, but If that's what it takes, I'll rewrite it again then. .
9/16/2002: Today's Prolongevity Update presents:
(1) a quotation of John Furber's remarks about the immortality of germ cells.
(2) Alteon Pharmaceutical's cross-link breaker
(3) Paragraph mentioning deinococcus radiodurans
9/15/2002: Today, I discovered that the "Prolongevity_Discussion" page on this website has landed at the top the Google search list out of 21,000 entries. I have spent the afternoon updating it.
9/14/2002: Infamous Quotations
9/2/2002: Remarks on Rejuvenation.
8/27/2002: Longevity Research: Revisiting Ubiquity's May, 2000, Interview with Dr. Michael West
8/13/2002: This an update of the 8-9-15-2002_Editorials "published" a year age.
8-10-2002: On Living Another Day
7-30-2002: Rejuvenation and bonds
7-3-2002: Life Expectancies
May 22, 2002, Letter to Steve
4/14/2002: A bit of gossip: My sister mentioned tonight that she's reading a book written by a biogeneticist, who advises the reader that seeds and other organisms are born young even though they're the products of somewhat-aged cells. Somehow, Nature has a way of completely resetting their biological clocks. I've been stating this, but without official confirmation that this is truly the case. But I guess we've found it. Nature has revealed that she totally and routinely rejuvenates organisms across the biological spectrum. Now it's up to us to figure out how she does it.
4/9/2002: One comment about longevity research. It seems to me to be an unavoidable conclusion that nature has some way of cleaning up not only the genome but the entire cell when biogenesis occurs. Otherwise, if a baby were born 20 years old, and its child were born 40 years old, and its grandchild were born 60 years old... you can see where this is going. If it proves possible to replicate the enzymes and other biochemical agents that must operate within an oocyte immediately after fertilization, and to apply these to adult cells, all other longevity research would seem to be overtaken by events.
Although I haven't seen discussions of research into these phenomena in the first few search returns I've found, that might not necessarily mean that it isn't taking place. With 1 in 3 people in the developed world approaching retirement, and 1.2 billion people retired by 2050, hundreds of billions of dollars a year could accrue to whatever corporation cuts this Gordian knot first. You could see why involved organizations might possibly choose caginess over candor.
Tonight's other topic concerns longevity research, or "prolongevity". One excellent web page concerning this subject is offered by John Furber. . Following the leads listed on his page, I found that Bruce Ames, et al, is finding that the gamma form of vitamin-E, gamma-tocopherol, may play an important role in cancer prevention and age-retardation. There are also discussions of the fact that the alpha lipoic acid + acetyl-l-carnitine that I've been touting requires the R-enantiomer of alpha-lipoic acid rather than the usual over-the-counter form of the substance.
The recommended daily dosage levels for alpha lipoic acid are in the 120 milligram to 1 gram range. I'm back to trying higher dosage levels.
I believe that there may really be agents and protocols that will already extend lifespan. I think they're already showing up in our populations. (One in three people in the U. S. are projected to be retired in the 2020-2030 time frame.)
Ageing process 'key' pinpointed - BBC
"Is human aging still mysterious enough to be left only to scientists?"
Transcript of the SENS I Roundtable
SENS (Strategies for Engineered Negligible Senescence)
National Cancer Institute Awards Contract to Test AGI's Dimericine in Renal Transplant Patients to Reduce Skin Cancer
Dimericine and DNA Repair
Can We Prevent Aging?
Research: Genetic Errors Cause Aging
How Realistic Is Total Rejuvenation?
The Limits of Human Life Span
Update on "Viva Immortalis"
Can Aging Be Reversed?
My 60-Year Assignation with Longevity Research
Are We Ready for a "Manhattan Project" in Longevity?
Gene Mutation Extends Lifespan In "I'm Not Dead Yet" Fruitflies
Total Rejuvenation Wouldn't Be a Panacea
Aging Breakthrough- Cloning Super-Juvenates Cells
On Living Forever - Interview with Dr. Michael West
Reflections on Rejevenation
Target for Repairing Damaged Cells Found In the Telomerase Enzyme
Ageing process 'key' pinpointed - BBC
5/21/2004: The Cell, and Farrukh Saleem Quotes John Kerry