The Mega Foundation

The Lifetime-Energy-Budget Model

April 20, 2004


Assumptions

* - "Calories" refers to kilocalories, per common usage.

Life
span

* - I'm assuming that the average lifespan for our hypothetical male might be 80 years if he were immersed in the same kind of  controlled and protected environment that we provide for animal models.

Effect of Caloric-Restriction upon Flowering, and Reproduction

Effects of Caloric-Restriction upon the Sizes of Growing Children

Genetic Changes with Caloric-Restriction from Birth

Effect of Caloric-Restriction upon The Shape of the Survival Curve

Calorie Restriction Late in Life

Calorie Restriction and Weight Loss

Effects of Antioxidants and Other Biochemical Interventions


    A review of the predictions of this lifetime-energy-budget model shows that it falls wide of the mark in  fitting the experimental evidence. It's a seductive model. It fits with our intuitive ideas about cars and other mechanical gadgets... they wear out... but it seems to me to fail to account for negligibly senescent animals such as the red sea urchin and the rough-eyed rockfish. In any case, it's at odds with late-in-life gene reversions when an organism goes on a CRON diet. It's tempting to think of CR in simple terms of metabolic rates, but that may not be the whole story. ."Selected Contribution: Long-lived Drosophila melanogaster lines exhibit normal metabolic rates" and Live fast, die old  - Nature. 
    So if this isn't a realistic model of caloric-restriction, what is?

 

What We Actually Observe with Calorie Restriction

Lifespan vs. Degree of Calorie Restriction

Effects of Caloric-Restriction upon the Sizes of Growing Animals

Effect of Caloric-Restriction upon Flowering, and Reproduction

Genetic Changes with Caloric-Restriction from Birth

Caloric Restriction Later in Life

Genetic Changes with Caloric-Restriction Later in Life



From Presentation: Anti-Aging Drug Discovery Development Summit, Oct. 15, 2002Presented by- Dr. Xi Zhao-Wilson, Dr. Stephen Splindler

image

    In examining this triplet of curves, it's interesting to note that the rightmost curve, denoting lifelong caloric-restriction, appears to be stretched out along the abscissa, whereas the middle curve, representing starting CR at the beginning of old age, has almost the same shape as the control group except that it's shifted to the right.

Home

Future Index